Wednesday, April 27, 2011

Massachusetts team Identify Marker for Diabetes

It may be possible in the near future to gauge whether an individual is susceptible to develop diabetes.  It has been found from studies conducted by researchers from Massachusetts general hospital and the broad institute of MIT and Harvard that higher levels of specific amino acids ( isoleucine, tyrosine and phenylalnine) and triacylgylcerides (TAGs) with shorter chain length and fewer double bonds in the blood  are marker of increased risk of developing diabetes. 

In the two studies, the serum samples of 378 participants were studied.  The serum samples for those patients who went to develop diabetes were evaluated for different metabolites/lipids that were present in different concentrations in the blood compared with the in the blood of those who did not.   

It was found that the top quartile of patients with highest amino acid signature (isoleucine, tyrosine and phenylalnine), had a sixfold greater risk of developing diabetes than those in the bottom quartile. Similarly top quartile TAG signature patients had a 4.3 fold higher risk of becoming diabetic than bottom quartile TAG signature patients.

This is a first step forward to getting a highly predictive marker for diabetes, while further efforts in this direction would be able to yield better medicines for diabetes in the future.

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