Friday, January 20, 2012

Glioblastoma Multiforme - EU CHMP recommend 3 years of Adjuvant Glivec use post surgery

The CHMP opinion was based on data from a multicenter, open-label, Phase III clinical trial. Results of the study, which were first presented in June 2011 at the American Society of Clinical Oncology plenary session, showed that at five years, 66% of patients taking Glivec for three years after surgery for KIT+ GIST remained free of cancer recurrence (primary endpoint), compared to 48% who had received Glivec for only one year after surgery (p<0.0001). In addition, at five years, 92% of patients taking Glivec for three years after surgery were alive (secondary endpoint) compared to 82% who had received Glivec for only one year after surgery (p=0.019).